Showing posts with label DNA. Show all posts
Showing posts with label DNA. Show all posts

Friday, 22 February 2013

Meet The Izzards


BBC1 screened a very interesting programme over the nights of Wednesday 20th February and Thursday 21st February 2013. In Meet The Izzards comedian, actor, and marathon runner Eddie Izzard used state of the art DNA analysis techniques to discover where his family originated from. The first programme dealt with his mother's line, while the second focused on his father's lineage. Each was extremely illuminating.

The start of the first programme promised an epic journey over ten thousand generations of ancestry, a task that can only now be completed for the first time using new DNA analysis techniques. Eddie began by visiting the genetic science department at the University of Edinburgh, where his DNA was analysed and recorded.

Genetic mapping involves discovering markers in shared DNA. Put very simply, these markers can denote ancestry in specific areas of the world at certain times. The marker 'L' is the earliest and refers to Africa and the origin of all human existence. Eddie's first stop on his journey was therefore Africa, specifically Namibia.

There he met a local tribe who taught him about their hunter-gatherer existence, which is very similar to how Eddie's ancestors would have lived two hundred thousand years ago. Eddie's second key marker revealed that his ancestors lived in East Africa around sixty thousand years ago, so that is where he travelled to next.

In fact, his destination was the point at which it is believed the earliest humans first left Africa. Eddie planned to retrace his ancestor's footsteps across the Bab-el-Mandeb strait into Yemen, where coincidentally he was born, however political unrest meant that he was unable to do so.

The next significant marker was from around eighteen thousand years ago in the Middle East. This is particularly important in the development of humankind, as it relates to the birth of agriculture. Eddie visited Turkey where he learnt about how humans overcame an intolerance to animal milk as a result of genetic changes. He also learnt that everybody with blue eyes, like Eddie himself, can be traced back to the Black Sea coast 10,000 years ago.

From here there were two main migration routes into Europe: into southern Europe, and into central and northern Europe. Eddie's direct ancestors on his mother's side moved north, specifically into Scandinavia. Since this marker relates to only 2000 years ago Eddie was able to meet people in Denmark who share direct genetic ancestors with him.

Eddie's next genetic marker on his mother's side was in England in around 500-1000AD, meaning most likely that he had Viking ancestors who travelled to the country during this time.

After exhausting his mother's lineage Eddie turned his attention to his father's DNA ancestry in the second episode of Meet The Izzards. Eddie's father had already managed to trace his family tree back to around 1650, but DNA analysis allows research to extend much further back into history, although not to the specificity of individual ancestors.

The oldest known marker of the male 'Y' chromosome dates to around 150,000 years ago in Cameroon, Africa. All modern males are genetically linked to this one ancestor. Eddie visited the Equatorial Rainforest to meet a local tribe and learn about hunting-gathering, much as he had done in the first episode. As with his maternal line, his paternal DNA shows that his ancestors crossed the Red Sea from Africa into Arabia.

A new piece of information, however, was that Eddie's DNA is 2.8% Neanderthal, which is higher than average. It is believed that Neanderthals, an entirely difference species from Homo Sapiens, were white in complexion and originated from Europe, whereas the earliest humans were black and from Africa.

Eddie's next important genetic marker, known as 'I2', links him to central Europe around 20,000 years ago. This was around the time of the last Ice Age, meaning that Eddie's ancestors would have had to have adapted well to the conditions in order to survive. After the end of the Ice Age Eddie's ancestors migrated to Saxony, and from there on to England as Saxons, most likely around 500AD.

Part travel show, part history lesson, Meet The Ancestors was both interesting and entertaining. It is fascinating to think that everybody on the planet is linked genetically if you go back far enough. If you missed the programme then I highly suggest you catch it on the BBC iPlayer, or alternatively check out the website.

Monday, 4 February 2013

The Remains of Richard III

Efforts are underway today to finally uncover the long lost grave of the English king Richard III. Richard, who allegedly arranged for the murder of his two young nephews in the "princes in the Tower" story, was killed in the Battle of Bosworth in 1485.

The exact whereabouts of his grave and remains has been lost over time, but historical records show that the body was taken to the church of the Greyfriars Franciscan friary in Leicester. That building has long since disappeared, but archaeologists believe that they can locate it under a modern car park.

If they are successful, and they find the church and human remains, then DNA testing will be carried out. From a genealogical perspective this is amazing, as the DNA of the remains will be compared with a modern descendant of Richard III. Canadian Joy Ibsen, now deceased, was confirmed as a descendant of the royal line, and had previously had her DNA sampled to be used in Plantagenet genealogy research.

It is going to be very interesting to discover if the remains of the famous Richard III have finally be found, and how this will enhance our understanding of the man and his life.

UPDATE: Excavation work at the site has revealed the church, chapter house, cloisters.....and reasonably well preserved human remains. These remains have now been sent for DNA analysis, which should take between 8-12 weeks. After this point we will know if the final resting place of Richard III has been discovered. 

UPDATE: At a press conference this morning (Monday 4th February 2013) researchers from the University of Leicester confirmed that the remains found in a Leicester car park were indeed those of King Richard III. The DNA evidence, in conjunction with the genealogical evidence carried out by the university's project genealogist Professor Kevin Schurer, confirms beyond reasonable doubt that the skeleton is that of Richard III. His remains will now be buried in Leicester Cathedral.

Monday, 12 November 2012

Scottish DNA

A new research study is being launched by ScotlandsDNA into the three different types of gene for red hair, with the specific purpose of discovering why Scotland has such an abundance of red headed people. Around 13% of people in Scotland have red hair, compared to a global figure of 1-2%. The researchers believe, however, that in Scotland alone there could be over one-and-a-half million. It is interesting to note that red hair can skip generations in the same family. 

The aim of the research project is to accurately map the number of Scottish carriers of one of the three types of genes that can lead to red hair. The researchers are hoping to be able to establish a theory for Scotland being the most red-headed nation in the world.

The amount of emigration from Scotland throughout the centuries has clearly contributed to the global total of red headed people. It would be extremely interesting to expand the study to include genealogical data, although this is obviously outwith the scope currently. 


Wednesday, 18 April 2012

Using DNA Testing In Genealogy

I just read a very interesting genealogy article on the BBC website, entitled "How I Traced My Ancestry Back To The Stone Age." Now, the headline was obviously designed to pique the interest of any genealogist, although as it turned out it was a little misleading. 

The article was written by a genealogist who had been researching her Ashkenazi Jewish ancestry for years. Due to the changes that have occurred in Europe over the years in terms of countries' borders changing, she found it very difficult to determine exactly where her ancestors came from. This led her to investigate DNA testing, which is the main focus of the article.

The article explains how there are companies who will, for a fee, take a sample of your DNA, and test it using a process known as genotyping. By comparing DNA with a database of known reference populations these companies can determine where in the world your ancestors were most likely to have come from. As an example, a huge percentage of the inhabitants of the Orkney Islands have common DNA with Scandinavians, due to the invasion and habitation of those islands by the Vikings from around the ninth century.

The results of the author's DNA test confirmed her European Jewish heritage, and pinpointed her ancestry to modern day Russia, Poland, and Belarus.There were also links to the Iberian Peninsula fifteen thousand years ago. Amazingly, the test could also prove that the author had Neanderthal DNA, hence the title of the article.

It appears that this technology can be another method used by genealogists to unravel their family history. It is, of course, impossible to trace your family tree back to the Stone Age, but it is nevertheless fascinating and useful to have an idea of where your distant ancestors came from. In addition, genome research is expected to become much more advanced in the next few years, meaning that ancestry can be accurately pinpointed to very specific locations, such as an individual village.

Exciting times ahead...